AT1001 | α3β4 nAChR inhibitor | Probechem Biochemicals

Chemical Structure : AT1001

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AT1001 (AT-1001)

货号: PC-49428Not For Human Use, Lab Use Only.

AT1001 (AT-1001) is a high affinity and selective α3β4 nAChR antagonist with Ki value of 2.4 nM, >90-fold selectivity over the other major subtypes (α4β2 and α7 nAChR).

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生物&药学活性

AT1001 (AT-1001) is a high affinity and selective α3β4 nAChR antagonist with Ki value of 2.4 nM, >90-fold selectivity over the other major subtypes (α4β2 and α7 nAChR).
AT1001 potently and reversibly blocks epibatidine-induced inward currents in HEK cells transfected with α3β4 nAChR.
AT-1001 potently and dose-dependently blocks nicotine self-administration in rats, without affecting food responding.
AT-1001 inhibits nicotine-induced [3H]dopamine release poorly and at significantly higher concentrations compared with mecamylamine and conotoxin MII in nucleus accumbens (NAcs) synaptosomal preparation.

物理化学性质&存储条件

分子量	309.251
分子式	C15H21BrN2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(2-bromophenyl)-9-methyl-9-azabicyclo[3.3.1]nonan-3-amine

参考文献

1. Toll L, et al. Neuropsychopharmacology. 2012 May;37(6):1367-76.

AT1001 (AT-1001)

生物&药学活性

物理化学性质&存储条件

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AT1001 (AT-1001)

生物&药学活性

物理化学性质&存储条件

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