AT-130 |CAS:211364-06-6 Probechem Biochemicals

Chemical Structure : AT-130

CAS No.: 211364-06-6

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AT-130 (AT130)

货号: PC-63327Not For Human Use, Lab Use Only.

AT-130 is a potent inhibitor of HBV capsid assembly, inhibits wild-type HBV replication with IC50 of 2.4 uM.

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5 mg	￥1780	In stock
10 mg	￥2880	In stock
25 mg	￥4780	In stock
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100 mg		Get quote

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生物&药学活性

AT-130 is a potent inhibitor of HBV capsid assembly, inhibits wild-type HBV replication with IC50 of 2.4 uM.
AT-130 inhibits replication of wild-type and lamivudine-resistant strains of hepatitis B virus in vitro with same sensitivity (rtL180M, rtM204I, and rtL180M + rtM204V); blocks HBV replication at the level of viral RNA packaging, interferes with capsid morphogenesis.
AT-130 shows activity against the main lamivudine- and adefovir-resistant mutants.

物理化学性质&存储条件

分子量	488.338
分子式	C22H22BrN3O5
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(E)-N-(1-bromo-1-(2-methoxyphenyl)-3-oxo-3-(piperidin-1-yl)prop-1-en-2-yl)-4-nitrobenzamide

参考文献

1. Delaney WE 4th, et al. Antimicrob Agents Chemother. 2002 Sep;46(9):3057-60.

2. Feld JJ, et al. Antiviral Res. 2007 Nov;76(2):168-77.

3. Billioud G, et al. Antiviral Res. 2011 Nov;92(2):271-6.

AT-130 (AT130)

生物&药学活性

物理化学性质&存储条件

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AT-130 (AT130)

生物&药学活性

物理化学性质&存储条件

参考文献

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