AT-121 | MOP/NOP agonist | Probechem Biochemicals

Chemical Structure : AT-121

CAS No.: 2099681-31-7

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AT-121 (AT121)

货号: PC-27539Not For Human Use, Lab Use Only.

AT-121 (AT121) is a potent, selective bifunctional nociceptin/orphanin FQ peptide / Mu opioid peptide (NOP/MOP) receptor agonist with Ki of 3.67/16.49 nM, respectively.

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生物&药学活性

AT-121 (AT121) is a potent, selective bifunctional nociceptin/orphanin FQ peptide / Mu opioid peptide (NOP/MOP) receptor agonist with Ki of 3.67/16.49 nM, respectively.
AT-121 showshigh potency (EC50=35 nM) and partial agonist efficacy at the NOP receptor relative to N/OFQ, and high potency (EC50=20 nM) and partial agonist activity at the MOP receptor, relative to DAMGO.
AT-121 shows significantly lower binding affinity at the DOP or KOP receptors (Ki >100 nM).
AT-121 (0.003-0.03 mg/kg, s.c. injection) produces potent antinociceptive and antiallodynic effects in nonhuman primates and humans.
AT-121 does not induce side effects commonly associated with opioids, such as respiratory depression, abuse potential, opioid-induced hyperalgesia, and physical dependence.

物理化学性质&存储条件

分子量	462.65
分子式	C24H38N4O3S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	Sulfamide, N-[2-[1,2-dihydro-1'-[cis-4-(1-methylethyl)cyclohexyl]-3-oxospiro[isoquinoline-4(3H),4'-piperidin]-2-yl]ethyl]-

参考文献

1. Ding H, et al. Sci Transl Med. 2018 Aug 29;10(456):eaar3483.

2. Elawy BE, et al. PLoS One. 2026 Apr 20;21(4):e0347529.

AT-121 (AT121)

生物&药学活性

物理化学性质&存储条件

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AT-121 (AT121)

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