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首页-小分子抑制剂&激动剂-Others-Other Targets-ASX-173
ASX-173

Chemical Structure : ASX-173

CAS No.: 2748800-08-8

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ASX-173 (ASX173)

货号: PC-25795Not For Human Use, Lab Use Only.

ASX-173 is a selective, cell-penetrable small molecule inhibitor of human asparagine synthetase (ASNS), inhibits L-asparagine production with IC50 of 0.5 uM,, induces the integrated stress response (ISR), and reduces cell growth in HEK-293A cells.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

ASX-173 is a selective, cell-penetrable small molecule inhibitor of human asparagine synthetase (ASNS), inhibits L-asparagine production with IC50 of 0.5 uM,, induces the integrated stress response (ISR), and reduces cell growth in HEK-293A cells.
ASX-173 is an uncompetitive inhibitor with respect to Mg2+/ATP
ASX-173 binds to the synthetase site of human ASNS.
ASX-173 does not bind to evolutionarily related ATP pyrophosphatases, such as GMP synthetase (GMPS) and argininosuccinate synthetase (ASS1).

物理化学性质&存储条件

分子量 475.56
分子式 C28H30FN3O3
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(2R,3S,4R)-1-((S)-2-aminobutanoyl)-N-benzhydryl-4-(4-fluorophenyl)-3-hydroxypyrrolidine-2-carboxamide

参考文献

1. Staschke KA, et al. bioRxiv [Preprint]. 2025 Oct 17:2025.10.

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