ASTX660 mesylate |CAS:1799328-90-7 Probechem Biochemicals

Chemical Structure : ASTX660 mesylate

CAS No.: 1799328-90-7

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ASTX660 mesylate (ASTX 660;ASTX-660)

货号: PC-63393Not For Human Use, Lab Use Only.

ASTX660 mesylate is a novel potent IAP antagonist that targets the BIR3 domain of cIAP1/2 and XIAP with IC50 of 12 nM and <40 nM.

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25 mg	￥2880	In stock
50 mg	￥4980	In stock
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生物&药学活性

ASTX660 mesylate is a novel potent IAP antagonist that targets the BIR3 domain of cIAP1/2 and XIAP with IC50 of 12 nM and <40 nM.
ASTX660 potently inhibits association between XIAP and caspase 9 in HEK293 cell line with EC50 of 2.8 nM, binds to and leads to the degradation of cIAP1/2 and stabilisation of NIK in cell.
ASTX660 induces apoptosis in MDA-MB-231 cells with EC50 of 1.8 nM, which is TNF-α-dependent.
ASTX660 inhibits tumor growth in mice bearing breast and melanoma tumor xenografts.

物理化学性质&存储条件

分子量	635.796
分子式	C31H46FN5O6S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	1-(6-(4-fluorobenzyl)-5-(hydroxymethyl)-3,3-dimethyl-2,3-dihydro-1H-pyrrolo[3,2-b]pyridin-1-yl)-2-((2R,5R)-5-methyl-2-(((R)-3-methylmorpholino)methyl)piperazin-1-yl)ethan-1-one methanesulfonate

参考文献

1. Ward GA, et al. Mol Cancer Ther. 2018 Apr 25. pii: molcanther.0848.2017.

ASTX660 mesylate (ASTX 660;ASTX-660)

生物&药学活性

物理化学性质&存储条件

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ASTX660 mesylate (ASTX 660;ASTX-660)

生物&药学活性

物理化学性质&存储条件

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