ASS234 |CAS:1334106-34-1 Probechem Biochemicals

Chemical Structure : ASS234

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ASS234 (ASS-234, ASS 234)

货号: PC-35409Not For Human Use, Lab Use Only.

ASS234 (ASS-234) is a multitarget, potent, and CNS permeable inhibitor with IC50 of 5.2, 43, 350 and 460 nM for MAO-1, MAO-B, EeAChE and eqBuChE, respectively.

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生物&药学活性

ASS234 (ASS-234) is a multitarget, potent, and CNS permeable inhibitor with IC50 of 5.2, 43, 350 and 460 nM for MAO-1, MAO-B, EeAChE and eqBuChE, respectively.
ASS234 inhibits Aβ aggregation, possesses antioxidant properties and protects from Aβ-induced apoptosis in vitro.
ASS234 completely blocks the aggregation mediated by AChE of both Aβ1-42 and Aβ1-40, showing a dual binding site to AChE.
ASS234 significantly reduces Aβ1-42-mediated toxicity in SH-SY5Y human neuroblastoma cells, ASS234 is a promising multitarget drug candidates with potential impact for Alzheimer's disease.

物理化学性质&存储条件

分子量	443.635
分子式	C29H37N3O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-[[5-[3-(1-benzylpiperidin-4-yl)propoxy]-1-methylindol-2-yl]methyl]-N-methylprop-2-yn-1-amine

参考文献

1. Bolea I, et al. J Med Chem. 2011 Dec 22;54(24):8251-70.

2. Bolea I, et al. Curr Alzheimer Res. 2013 Oct;10(8):797-808.

3. del Pino J, et al. CNS Neurosci Ther. 2014 Jun;20(6):568-70.

4. Marco-Contelles J, et al. Front Neurosci. 2016 Jun 28;10:294.

ASS234 (ASS-234, ASS 234)

生物&药学活性

物理化学性质&存储条件

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ASS234 (ASS-234, ASS 234)

生物&药学活性

物理化学性质&存储条件

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