ASR352 | CAS 2288792-51-6 Probechem Biochemicals

Chemical Structure : ASR352

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ASR352 (ASR 352, ASR-352)

货号: PC-49085Not For Human Use, Lab Use Only.

ASR352 is a small molecule NSC30049 analog, inhibits the growth of CRC bulk cells, sensitizs FOLFOX-resistant cells, and reduces the sphere formation capacity of CRC stem cells.

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生物&药学活性

ASR352 is a small molecule NSC30049 analog, inhibits the growth of CRC bulk cells, sensitizs FOLFOX-resistant cells, and reduces the sphere formation capacity of CRC stem cells.
The mechanism of cytotoxicity for ASR352 includes abrogation of 5-FU-induced the S phase, reduction of the phosphorylation of Chk1 at S317P, S345P and S296P, increased γH2AX staining, activation of caspase 3/PARP1 cleavage, and enhancement of Bax/Bcl2 ratio.

物理化学性质&存储条件

分子量	306.838
分子式	C16H23ClN4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(E)-1-(4-phenylbut-2-en-1-yl)-1,3,5,7-tetraazaadamantan-1-ium chloride

参考文献

1. Satya Narayan, et al. Eur J Med Chem. 2019 Jan 1;161:456-467.

ASR352 (ASR 352, ASR-352)

生物&药学活性

物理化学性质&存储条件

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ASR352 (ASR 352, ASR-352)

生物&药学活性

物理化学性质&存储条件

参考文献

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