ASP 9853 |CAS:442198-67-6 Probechem Biochemicals

Chemical Structure : ASP9853

CAS No.: 442198-67-6

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ASP9853 (ASP 9853; ASP-9853; FR 260330 dehydrate)

货号: PC-60993Not For Human Use, Lab Use Only.

ASP9853 is a potent, orally active iNOS inhibitor (IC50=10 nM, NO release DLD-1 cells) that prevents dimerization of iNOS, but has no effect on the expression or enzyme activity of iNOS.

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生物&药学活性

ASP9853 is a potent, orally active iNOS inhibitor (IC50=10 nM, NO release DLD-1 cells) that prevents dimerization of iNOS, but has no effect on the expression or enzyme activity of iNOS.
ASP9853 reduces NOx production in plasma from rats exposed to LPS (IC50=1.6 mg/kg), without effect on mean arterial blood pressure.
ASP9853 also shows greater tumor growth inhibition than docetaxel alone against non-small lung cancer xenografts in combination with docetaxe.

物理化学性质&存储条件

分子量	617.026
分子式	C29H28ClF3N6O4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(S,E)-3-(4-chlorophenyl)-N-(1-oxo-1-((2-oxo-2-(4-((6-(trifluoromethyl)pyrimidin-4-yl)oxy)piperidin-1-yl)ethyl)amino)-3-(pyridin-2-yl)propan-2-yl)acrylamide

参考文献

1. Luke JJ, et al. Cancer Chemother Pharmacol. 2016 Mar;77(3):549-58.

2. Chida N, et al. Eur J Pharmacol. 2005 Feb 10;509(1):71-6.

ASP9853 (ASP 9853; ASP-9853; FR 260330 dehydrate)

生物&药学活性

物理化学性质&存储条件

参考文献

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询单

ASP9853 (ASP 9853; ASP-9853; FR 260330 dehydrate)

生物&药学活性

物理化学性质&存储条件

参考文献

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