ASP9436 |CAS:1401807-89-3 Probechem Biochemicals

Chemical Structure : ASP9436

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ASP9436 (ASP-9436;ASP 9436)

货号: PC-60996Not For Human Use, Lab Use Only.

ASP9436 (ASP-9436) is a potent, selective brain penetrant and orally active phosphodiesterase 10A (PDE10A) inhibitor with IC50 of 8.0 nM, >420-fold selectivity over other PDE subtypes.

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25 mg		Get quote
100 mg		Get quote
200 mg		Get quote
1 g		Get quote

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生物&药学活性

ASP9436 (ASP-9436) is a potent, selective, brain penetrant and orally active phosphodiesterase 10A (PDE10A) inhibitor with IC50 of 8.0 nM, >420-fold selectivity over other PDE subtypes.
ASP9436 attenuates locomotor activity with ED50 of 7.0 mg/kg, and improves visual-recognition memory deficit in animal model for the positive symptoms of schizophrenia.

物理化学性质&存储条件

分子量	498.408
分子式	C25H25Cl2N5O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
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Solubility	10 mM in DMSO
Chemical Name/SMILES	1-methyl-5-(1-methyl-3-{[4-(1-methyl-1H-benzimidazol-4-yl)phenoxy]methyl}-1H-pyrazol-4-yl)pyridin-2(1H)-one dihydrochloride

参考文献

1. Hamaguchi W, et al. Bioorg Med Chem. 2015 Jul 1;23(13):3351-67.

ASP9436 (ASP-9436;ASP 9436)

生物&药学活性

物理化学性质&存储条件

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ASP9436 (ASP-9436;ASP 9436)

生物&药学活性

物理化学性质&存储条件

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