ASP 8477 |CAS:906737-25-5 Probechem Biochemicals

Chemical Structure : ASP 8477

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ASP 8477 (ASP8477;ASP-8477)

货号: PC-60985Not For Human Use, Lab Use Only.

ASP8477 is a novel potent, highly selective fatty acid amide hydrolase (FAAH) inhibitor with IC50 of 0.99, 1.65 and 57.3 nM for human FAAH-1, FAAH-1 (P129T) and FAAH-2, respectively.

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生物&药学活性

ASP8477 is a novel potent, highly selective fatty acid amide hydrolase (FAAH) inhibitor with IC50 of 0.99, 1.65 and 57.3 nM for human FAAH-1, FAAH-1 (P129T) and FAAH-2, respectively.
ASP8477 displays no appreciable binding affinity to or inhibition against a panel of 65 receptors, ion channels and transporters, including CB1, CB2 receptors and MAGL.
ASP8477 elevates AEA concentrations in both plasma and brain in adolescent rats, significantly improves mechanical allodynia and thermal hyperalgesia in capsaicin-induced secondary hyperalgesia model (0.3-3mg/kg, p.o).

物理化学性质&存储条件

分子量	325.368
分子式	C18H19N3O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	3-pyridyl 4-(phenylcarbamoyl)piperidine-1-carboxylate

参考文献

1. Watabiki T, et al. Eur J Pharmacol. 2017 Nov 15;815:42-48.

2. Bradford D, et al. Pain Med. 2017 Dec 1;18(12):2388-2400.

ASP 8477 (ASP8477;ASP-8477)

生物&药学活性

物理化学性质&存储条件

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ASP 8477 (ASP8477;ASP-8477)

生物&药学活性

物理化学性质&存储条件

参考文献

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