ASP7663 | TRPA1 agonist | Probechem Biochemicals

Chemical Structure : ASP7663

CAS No.: 1190217-35-6

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ASP7663 (ASP 7663, ASP-7663)

货号: PC-61156Not For Human Use, Lab Use Only.

ASP7663 is a potent, selective, orally active TRPA1 receptor agonist with EC50 of 0.51, 0.54 and 0.50 uM for human, rat and mouse TRPA1, respectively.

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5 mg	￥980	In stock
10 mg	￥1480	In stock
25 mg	￥2480	In stock
50 mg	￥3980	In stock
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生物&药学活性

ASP7663 is a potent, selective, orally active TRPA1 receptor agonist with EC50 of 0.51, 0.54 and 0.50 uM for human, rat and mouse TRPA1, respectively.
ASP7663 concentration-dependently stimulates 5-HT release from QGP-1 cells with EC50 of 72.5 uM.
ASP7663 significantly improves the loperamide-induced delay in colonic transit in mice, also significantly inhibits colorectal distension (CRD)-induced abdominal pain response in rats.

物理化学性质&存储条件

分子量	263.268
分子式	C14H14FNO3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(E)-[7-fluoro-1-(2-methylpropyl)-2-oxo-1,2-dihydro-3H-indol-3-ylidene]aceticacid

参考文献

1. Kojima R, et al. Eur J Pharmacol. 2014 Jan 15;723:288-93.

ASP7663 (ASP 7663, ASP-7663)

生物&药学活性

物理化学性质&存储条件

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ASP7663 (ASP 7663, ASP-7663)

生物&药学活性

物理化学性质&存储条件

参考文献

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