ASP6918 | KRAS G12C inhibitor | Probechem Biochemicals

Chemical Structure : ASP6918

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ASP6918 (ASP 6918, ASP-6918)

货号: PC-21640Not For Human Use, Lab Use Only.

ASP6918 (ASP 6918) is a highly potent, covalent KRAS G12C inhibitor with IC50 of 28 nM in cell-free assays, and pERK inhibition IC50 of 3.7 nM in NCI-H1373 cells.

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生物&药学活性

ASP6918 (ASP 6918) is a highly potent, covalent KRAS G12C inhibitor with IC50 of 28 nM in cell-free assays, and pERK inhibition IC50 of 3.7 nM in NCI-H1373 cells.
ASP6918 potently inhibits cell growth of NCI-H1373 cell line with IC50 of 6.1 nM.
ASP6918 induces significant suppression of ERK phosphorylation at doses of 40 and 60 mg/kg in an NCI-H1373 xenograft mouse model.
ASP6918 (10-60 mg/ kg, p.o.) exhibits antitumor growth inhibition and regression in an NCI-H1373 xenograft mouse model.

物理化学性质&存储条件

分子量	621.79
分子式	C36H43N7O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(+)-1-(7-{8-ethoxy-7-(5-methyl-1H-indazol-4-yl)-2-[(1-methylpiperidin-4-yl)oxy]-6-vinylquinazolin-4-yl}-2,7-diazaspiro[3.5]non-2-yl)prop-2-en-1-one

参考文献

1. Tomoyoshi Imaizumi, et al. Bioorg Med Chem. 2023 Dec 27:98:117581.

ASP6918 (ASP 6918, ASP-6918)

生物&药学活性

物理化学性质&存储条件

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ASP6918 (ASP 6918, ASP-6918)

生物&药学活性

物理化学性质&存储条件

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