ASP5878 |CAS:1453208-66-6 Probechem Biochemicals

Chemical Structure : ASP5878

CAS No.: 1453208-66-6

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ASP5878 (ASP-5878, ASP 5878)

货号: PC-70221Not For Human Use, Lab Use Only.

ASP-5878 (ASP5878) is a novel potent, selective pan-FGFR inhibitor with IC50 of 0.47/0.60/0.74/3.5 nM for FGFR1/2/3/4, respectively.

规格	价格	库存
5 mg	￥1980	In stock
10 mg	￥2980	In stock
25 mg	￥4980	In stock
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100 mg		Get quote

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生物&药学活性

ASP-5878 (ASP5878) is a novel potent, selective pan-FGFR inhibitor with IC50 of 0.47/0.60/0.74/3.5 nM for FGFR1/2/3/4, respectively.
ASP-5878 also inhibits FGFR3 (K650E), FGFR3 (K650M), VEGFR2, FGFR4 (N535K), FMS with IC50 of 1.6, 4.2, 25, 78, 150 nM, respectively.
ASP-5878 potently suppressed the growth of the FGF19-expressing hepatocellular carcinoma cell lines Hep3B2.1-7, HuH-7, and JHH-7 with IC50 of 8.5-27 nM.
ASP-5878 induces sustained tumor regression in a xenograft mouse model using Hep3B2.1-7. Orally bioactive.

物理化学性质&存储条件

分子量	407.378
分子式	C18H19F2N5O4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	DMSO: 250 mg/mL
Chemical Name/SMILES	2-(4-((5-((2,6-difluoro-3,5-dimethoxybenzyl)oxy)pyrimidin-2-yl)amino)-1H-pyrazol-1-yl)ethan-1-ol

参考文献

1. Futami T, et al. Mol Cancer Ther. 2017 Jan;16(1):68-75.

2. Kikuchi A, et al. Cancer Sci. 2017 Feb;108(2):236-242.

ASP5878 (ASP-5878, ASP 5878)

生物&药学活性

物理化学性质&存储条件

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ASP5878 (ASP-5878, ASP 5878)

生物&药学活性

物理化学性质&存储条件

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