ASP5736 | 5-HT5A antagonist | Probechem Biochemicals

Chemical Structure : ASP5736

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ASP5736 (ASP-5736)

货号: PC-49160Not For Human Use, Lab Use Only.

AS5736 is a potent, selective and brain-penetrating 5-HT5A receptor antagonist with Ki of 3.6, 1.7 and 4.4 nM against human, rat, mouse 5-HT5A receptors, respectively.

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生物&药学活性

AS5736 is a potent, selective and brain-penetrating 5-HT5A receptor antagonist with Ki of 3.6, 1.7 and 4.4 nM against human, rat, mouse 5-HT5A receptors, respectively.
AS5736 displays 30-fold greater selectivity for 5-HT5A over 5-HT7 receptor, and no significant affinity for 5-HT2A/2B/2C/3/4/6 receptors.
AS5736 (0.001-0.003 mg/kg, p.o.) ameliorated scopolamine-induced working memory deficit in mice and improved reference memory impairment in aged rats.
ASP5736 decreased the binding of LSD to 5-HT5A receptors in the olfactory bulb of rats in a dose-dependent manner and occupied 15%-50% of brain 5-HT5A receptors at behaviorally effective doses.

物理化学性质&存储条件

分子量	461.357
分子式	C20H14F3N5O5
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(diaminomethylene)-1-(3,5-difluoropyridin-4-yl)-4-fluoroisoquinoline-7-carboxamide fumarate

参考文献

1. Yamazaki M, et al. J Pharmacol Sci. 2015 Mar;127(3):362-9.

ASP5736 (ASP-5736)

生物&药学活性

物理化学性质&存储条件

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ASP5736 (ASP-5736)

生物&药学活性

物理化学性质&存储条件

参考文献

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