ASP3026 |CAS:1097917-15-1 Probechem Biochemicals

Chemical Structure : ASP3026

CAS No.: 1097917-15-1

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ASP3026 (ASP 3026;ASP-3026)

货号: PC-43495Not For Human Use, Lab Use Only.

ASP3026 is a potent small molecule ALK inhibitor with IC50 of 3.5, 10, 5.4 and 6.8 nM for wt ALK, ALK F1174L, ALK R1275Q and NPM1-ALK, respectively.

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10 mg	￥980	In stock
25 mg	￥1680	In stock
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100 mg		Get quote

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生物&药学活性

ASP3026 is a potent small molecule ALK inhibitor with IC50 of 3.5, 10, 5.4 and 6.8 nM for wt ALK, ALK F1174L, ALK R1275Q and NPM1-ALK, respectively.
ASP3026 also potently inhibits Ack, EGFR L858R, FRK and LTK with IC50 of 5-85 nM, inhibits the growth of NCI-H2228 cells with IC50 of 64.8 nM.
ASP3026 enhances the antitumor activities of paclitaxel and pemetrexed without affecting body weight in mice model.

物理化学性质&存储条件

分子量	580.74
分子式	C29H40N8O3S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	1,3,5-Triazine-2,4-diamine, N2-[2-methoxy-4-[4-(4-methyl-1-piperazinyl)-1-piperidinyl]phenyl]-N4-[2-[(1-methylethyl)sulfonyl]phenyl]-

参考文献

1. Mori M, et al. Mol Cancer Ther. 2014 Feb;13(2):329-40.

2. George SK, et al. Oncotarget. 2014 Jul 30;5(14):5750-63.

3. Mologni L, et al. Oncotarget. 2015 Mar 20;6(8):5720-34.

4. Iikubo K, et al. Chem Pharm Bull (Tokyo). 2018;66(3):251-262.

ASP3026 (ASP 3026;ASP-3026)

生物&药学活性

物理化学性质&存储条件

参考文献

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ASP3026 (ASP 3026;ASP-3026)

生物&药学活性

物理化学性质&存储条件

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