ASP2905 | KCNH3 inhibitor | Probechem Biochemicals

Chemical Structure : ASP2905

CAS No.: 792184-90-8

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ASP2905 (ASP 2905, ASP-2905)

货号: PC-60984Not For Human Use, Lab Use Only.

ASP 2905 (ASP2905) is a novel potent, selective, orally bioavailable inhibitor of voltage-gated potassium channel KCNH3 with IC50 of 9.0 nM.

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10 mg	￥980	In stock
25 mg	￥1680	In stock
50 mg	￥2980	In stock
100 mg		Get quote

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生物&药学活性

ASP2905 (ASP 2905) is a novel potent, selective, orally bioavailable inhibitor of voltage-gated potassium channel KCNH3 with IC50 of 9.0 nM.
ASP2905 displays minimally bound with low affinities to 55 transmembrane proteins.
ASP2905 decreases the frequency of spontaneous inhibitory postsynaptic currents in cultured rat hippocampal neurons at 0.1-1 uM.
ASP2905 reverses the disruption of spontaneous alternation behavior induced by MK-801 and scopolamine in mice, and ameliorates the cognitive deficits of aged rats.

物理化学性质&存储条件

分子量	388.41
分子式	C20H17FN8
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(4-fluorophenyl)-N'-phenyl-N''-(pyrimidin-2-ylmethyl)-1,3,5-triazine-2,4,6-triamine

参考文献

1. Takahashi S, et al. Eur J Pharmacol. 2017 Sep 5;810:26-35.

ASP2905 (ASP 2905, ASP-2905)

生物&药学活性

物理化学性质&存储条件

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ASP2905 (ASP 2905, ASP-2905)

生物&药学活性

物理化学性质&存储条件

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