ASP2205 | 5-HT2C agonist | Probechem Biochemicals

Chemical Structure : ASP2205

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ASP2205 (ASP2205 fumarate)

货号: PC-73306Not For Human Use, Lab Use Only.

ASP2205 (ASP2205 fumarate) is a potent, selective 5-HT2C receptor agonist with EC50 of 0.85/2.5 nM for human/rat 5-HT2C in the intracellular Ca2+ mobilization assays, respectively.

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生物&药学活性

ASP2205 (ASP2205 fumarate) is a potent, selective 5-HT2C receptor agonist with EC50 of 0.85/2.5 nM for human/rat 5-HT2C in the intracellular Ca2+ mobilization assays, respectively.
ASP2205 showed partial agonistic action on human 5-HT2A receptor with EC50 of 96 nM, no agonistic action against 5-HT2B.
ASP2205 (0.1-1 mg/kg, i.d.) significantly elevated the leak point pressure (LPP) in anesthetized rats in a dose-dependent manner.
ASP2205 is a more potent and selective 5-HT2C receptor agonist than lorcaserin.

物理化学性质&存储条件

分子量	416.518
分子式	C23H32N2O5
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	11-cyclopropyl-1-(2-methoxyethyl)-2,3,4,6,7,8,9,10-octahydro-1H-azepino[4,5-g]quinoline fumarate

参考文献

1. Ishigami T, et al. J Pharmacol Sci. 2019 Apr;139(4):333-339.

2. Klarskov N, et al. Neurourol Urodyn. 2019 Aug;38(6):1700-1706.

ASP2205 (ASP2205 fumarate)

生物&药学活性

物理化学性质&存储条件

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ASP2205 (ASP2205 fumarate)

生物&药学活性

物理化学性质&存储条件

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