ASP-6537 |CAS:524699-72-7 Probechem Biochemicals

Chemical Structure : ASP-6537

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ASP-6537 (ASP6537;ASP6537;FK-881;FK 881;FR 122047)

货号: PC-60430Not For Human Use, Lab Use Only.

ASP-6537 (FK 881, FR 122047) is a novel potent, selective, reversible cyclooxygenase-1 (COX-1) inhibitor with IC50 of 4.9 nM.

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生物&药学活性

ASP-6537 (FK 881, FR 122047) is a novel potent, selective, reversible cyclooxygenase-1 (COX-1) inhibitor with IC50 of 4.9 nM.
ASP-6537 displays 650-fold selectivity over COX-2 (IC50=3.2 uM).
ASP-6537 dose dependently inhibits carrageenan-induced paw edema (ED30=22 mg/kg) and paw swelling associated with adjuvant arthritis (ED50=17 mg/kg) in rats.
ASP-6537 also inhibits TXA2 production more selectively than aspirin in in vitro and in vivo, exerts potent antithrombotic effect in rats.

物理化学性质&存储条件

分子量	311.341
分子式	C17H17N3O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	3-methoxy-1,5-bis(4-methoxyphenyl)-1H-1,2,4-triazole

参考文献

1. Imanishi J, et al. Biochem Pharmacol. 2011 Oct 1;82(7):746-54.

2. Sakata C, et al. Thromb Res. 2013 Jul;132(1):56-62.

3. Sakata C, et al. Eur J Pharmacol. 2017 Mar 5;798:72-76.

ASP-6537 (ASP6537;ASP6537;FK-881;FK 881;FR 122047)

生物&药学活性

物理化学性质&存储条件

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ASP-6537 (ASP6537;ASP6537;FK-881;FK 881;FR 122047)

生物&药学活性

物理化学性质&存储条件

参考文献

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