ASN90 | O-GlcNAcase inhibitor | Probechem Biochemicals

Chemical Structure : ASN90

CAS No.: 1884154-02-2

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ASN90 (O-GlcNAcase inhibitor ASN90)

货号: PC-73139Not For Human Use, Lab Use Only.

ASN90 is a potent, selective, substrate-competitive O-GlcNAcase (OGA) inhibitor with IC50 of 10.2 nM.

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生物&药学活性

ASN90 is a potent, selective, substrate-competitive O-GlcNAcase (OGA) inhibitor with IC50 of 10.2 nM.
ASN90 does not inhibit hexosaminidase (Hex).
ASN90 induced protein O-GlcNAcylation in plated human and rodent PBMC with similar potencies (EC50 of 209 and 489 nM for human and rodent PBMC, respectively).
ASN90 is chemically distinct from carbohydrate-type substrate mimetic OGA inhibitors such as Thiamet G and MK-8719. ASN90 binds to the OGA enzyme in the living rat brain and robustly elevates the O-GlcNAcylation of brain proteins, including both tau and α-synuclein, in vivo.
ASN90 exhibited therapeutic efficacy in preclinical models of both tau and α-synuclein pathology.

物理化学性质&存储条件

分子量	375.447
分子式	C17H21N5O3S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
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Solubility	10 mM in DMSO
Chemical Name/SMILES	(S)-N-(5-(4-(1-(benzo[d][1,3]dioxol-5-yl)ethyl)piperazin-1-yl)-1,3,4-thiadiazol-2-yl)acetamide

参考文献

1. Permanne B, et al. ACS Chem Neurosci. doi: 10.1021/acschemneuro.2c00057.

ASN90 (O-GlcNAcase inhibitor ASN90)

生物&药学活性

物理化学性质&存储条件

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ASN90 (O-GlcNAcase inhibitor ASN90)

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物理化学性质&存储条件

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