ASN-002 |CAS:1425381-60-7 Probechem Biochemicals

Chemical Structure : ASN-002

CAS No.: 1425381-60-7

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ASN-002 (Gusacitinib;ASN002)

货号: PC-63126Not For Human Use, Lab Use Only.

ASN-002 (Gusacitinib, ASN002) is a novel and potent dual inhibitor of SYK/JAK kinases with IC50 of 5, 46, 4, 11 and 8 nM for SYK, JAK1, JAK2, JAK3 and TYK2, respectively, in biochemical assays.

规格	价格	库存
10 mg	￥1280	In stock
25 mg	￥1880	In stock
50 mg	￥2980	In stock
100 mg	￥4880	In stock
200 mg		Get quote
1 g		Get quote

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生物&药学活性

ASN-002 (Gusacitinib, ASN002) is a novel and potent dual inhibitor of SYK/JAK kinases with IC50 of 5, 46, 4, 11 and 8 nM for SYK, JAK1, JAK2, JAK3 and TYK2, respectively, in biochemical assays.
ASN-002 strongly suppresses the SYK and JAK family kinase signaling pathways measured as pLAT and pSTAT levels, respectively.
ASN-002 showed anti-proliferative activity in a broad panel of human cancer cell lines.
ASN-002 exhibits significant efficacy in inhibiting tumor growth in a multiple myeloma (H929) xenograft model.

物理化学性质&存储条件

分子量	460.542
分子式	C24H28N8O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	1-[5,6-Dihydro-4-[[4-(4-hydroxy-1-piperidinyl)phenyl]amino]-5-oxopyrimido[4,5-d]pyridazin-2-yl]-4-piperidineacetonitrile

参考文献

1. Sanjeeva Reddy, et al. Abstract 792: DOI: 10.1158/1538-7445.AM2015-792.

ASN-002 (Gusacitinib;ASN002)

生物&药学活性

物理化学性质&存储条件

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ASN-002 (Gusacitinib;ASN002)

生物&药学活性

物理化学性质&存储条件

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