ASM inhibitor 4i | ASM inhibitor | Probechem Biochemicals

Chemical Structure : ASM inhibitor 4i

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ASM inhibitor 4i (ASM-IN-1)

货号: PC-24103Not For Human Use, Lab Use Only.

ASM inhibitor 4i (ASM-IN-1) is a potent, selective inhibitor of acid sphingomyelinase (ASM) with IC50 of 1.5 uM.

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生物&药学活性

ASM inhibitor 4i (ASM-IN-1) is a potent, selective inhibitor of acid sphingomyelinase (ASM) with IC50 of 1.5 uM.
ASM inhibitor 4i (0.5, 1, 5, 10, and 20 μM) did not affect cell growth on HUVECs.
ASM inhibitor 4i effectively reduces the content of Cers in liver and plasma in C57BL/6 male mice.
ASM inhibitor 4i shows antiatherosclerotic activity by inhibiting ASM, completely different from simvastatin.
ASM inhibitor 4i could lessen lipid plaques in the aortic arch and aorta and reduce plasma ceramide concentration and Ox-LDL levels.
ASM inhibitor 4i significantly decrease LPS-induced and Ox-LDL-induced cell inflammation by regulating the levels of ceramide and sphingomyelin.

物理化学性质&存储条件

分子量	390.19
分子式	C16H12BrN3O4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	1,2,4-Oxadiazole-5-carboxamide, 3-[4-[(4-bromophenoxy)methyl]phenyl]-N-hydroxy-

参考文献

1. Yang K, et al. J Med Chem. 2023 Feb 23;66(4):2681-2698.

ASM inhibitor 4i (ASM-IN-1)

生物&药学活性

物理化学性质&存储条件

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ASM inhibitor 4i (ASM-IN-1)

生物&药学活性

物理化学性质&存储条件

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