ASK1-IN-19 |CAS:2089638-10-6 Probechem Biochemicals

Chemical Structure : ASK1-IN-19

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ASK1-IN-19 (ASK1 inhibitor 19)

货号: PC-60150Not For Human Use, Lab Use Only.

AKS1-IN-19 is a novel potent, selective and orally active ASK1 (MAP3K5) inhibitor with pIC50 of 8.3.

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生物&药学活性

AKS1-IN-19 is a novel potent, selective and orally active ASK1 (MAP3K5) inhibitor with pIC50 of 8.3.
AKS1-IN-19 displays good kinase selectivity with only 32 kinases having less than 30 fold selectivity in a panel of 356 kinases.
AKS1-IN-19 inhibits phospho-JNK with pEC50 of 8.2 in cellular assays.
AKS1-IN-19 displayed robust MAP3K pathway inhibition and reduction of infarct size in an isolated perfused heart model of cardiac injury.

物理化学性质&存储条件

分子量	393.447
分子式	C21H23N5O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(R)-2-(6-(4-(1-hydroxypropan-2-yl)-4H-1,2,4-triazol-3-yl)pyridin-2-yl)-6-isopropoxyisoindolin-1-one

参考文献

1. Lanier M, et al. ACS Med Chem Lett. 2017 Feb 8;8(3):316-320.

ASK1-IN-19 (ASK1 inhibitor 19)

生物&药学活性

物理化学性质&存储条件

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ASK1-IN-19 (ASK1 inhibitor 19)

生物&药学活性

物理化学性质&存储条件

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