ASC inhibitor MM01 | ASC inhibitor | Probechem Biochemicals

Chemical Structure : ASC inhibitor MM01

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ASC inhibitor MM01 (MM01)

货号: PC-72648Not For Human Use, Lab Use Only.

ASC inhibitor MM01 (MM01) is a first-in-class, specific small-molecule inhibitor of ASC protein that interferes with ASC speck formation, inhibited ASC-mediated pro-Casp-1 activation with IC50 of 0.5 uM.

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生物&药学活性

ASC inhibitor MM01 (MM01) is a first-in-class, specific small-molecule inhibitor of ASC protein that interferes with ASC speck formation, inhibited ASC-mediated pro-Casp-1 activation with IC50 of 0.5 uM.
MM01 does not target the active site of caspase-1.
MM01 (10 uM) inhibits ASC oligomerization/speck formation and facilitates ASC degradation in HEK293 cells.
MM01 inhibits ASC-dependent inflammasome activity, inhibits NLRP3-dependent inflammasome activity in vitro.
MM01 inhibits ASC-dependent inflammasome activity in stimulated murine peritoneal macrophages and in MSU-induced peritonitis mouse model.
MM01 (10mg/kg) efficiently suppressed MSU-induced IL-1β production and peritoneal neutrophil recruitment, with no effect on IL-6 and TNF-α secretion in murine mono-sodium urate (MSU)-induced model of peritonitis.
ASC (apoptosis-associated speck-like protein containing a caspase recruitment domain (CARD)) is a protein of the innate immune system that participates in the formation of inflammasomes, which are macromolecular complexes responsible for the maturation and release of pro-inflammatory cytokines.

物理化学性质&存储条件

分子量	318.37
分子式	C14H10N2O3S2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(Z)-3-(4-oxo-5-(2-oxoindolin-3-ylidene)-2-thioxothiazolidin-3-yl)propanal

参考文献

1. Soriano-Teruel PM, et al. Cell Death Dis. 2021 Dec 13;12(12):1155.

ASC inhibitor MM01 (MM01)

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