ASC69 (ASC-69, APY69) | MAP2K7 inhibitor | Probechem Biochemicals

Chemical Structure : ASC69

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ASC69 (APY69, ASC-69)

货号: PC-28485Not For Human Use, Lab Use Only.

ASC69 (ASC-69, APY69) is a small-molecule ligand as a PD/PD-L1 inhibitor, also potently inhibits MAP2K7 (MEK7, MKK7) with IC50 of 0.8 nM, inhibits T-ALL and elicits strong anti-leukemic effects by inducing cell-cycle arrest and apoptosis.

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生物&药学活性

ASC69 (ASC-69, APY69) is a small-molecule ligand as a PD/PD-L1 inhibitor, also potently inhibits MAP2K7 (MEK7, MKK7) with IC50 of 0.8 nM, inhibits T-ALL and elicits strong anti-leukemic effects by inducing cell-cycle arrest and apoptosis.
ASC69 induces cytotoxicity by inhibiting MAP2K7 and suppressing downstream JNK signaling in pediatric T-ALL.
ASC69 reduces JNK phosphorylation, decreases leukemic cell proliferation, causes cell cycle arrest, and induces apoptosis in a panel of T-ALL cell lines.
ASC69 inhibits the downstream JNK-ATF2 pathway.
ASC69 induced dose-dependent cytotoxicity in three independent T-ALL PDX models, with IC50 values of 50 nM (relapse T-ALL PDX02), 13 nM (relapse T-ALL PDX03), and 2.5 nM (remission T-ALL PDX04).
ASC69 synergizes with standard-of-care T-ALL drugs.

物理化学性质&存储条件

分子量	345.41
分子式	C19H19N7
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-(4-((4-((5-Cyclopropyl-1H-pyrazol-3-yl)amino)-6-methylpyrimidin-2-yl)amino)phenyl)acetonitrile

参考文献

1. Song Z, et al. J Med Chem. 2021;64(22):16687-16702.

2. Eric J Malmberg, et al. Res Sq [Preprint]. 2026 Aug 14:rs.3.rs-10474945.

3. Schröder M, et al. Cell Chem Biol 27:1285–1295e4.

ASC69 (APY69, ASC-69)

生物&药学活性

物理化学性质&存储条件

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ASC69 (APY69, ASC-69)

生物&药学活性

物理化学性质&存储条件

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