ASB 14780 |CAS:1069046-00-9 Probechem Biochemicals

Chemical Structure : ASB 14780

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ASB 14780 (ASB14780;ASB-14780)

货号: PC-60713Not For Human Use, Lab Use Only.

ASB 14780 (ASB14780, ASB-14780) is a potent, selective and orally active cytosolic phospholipase A2α (cPLA2α) inhibitor with IC50 of 20 nM.

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1 g		Get quote

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生物&药学活性

ASB 14780 (ASB14780, ASB-14780) is a potent, selective and orally active cytosolic phospholipase A2α (cPLA2α) inhibitor with IC50 of 20 nM.
ASB 14780 displays excellen selectivity over other known secreted phospholipase A2s (sPLA2s), such as sPLA2-IA, sPLA2-IIA, sPLA2-III, and sPLA2-IB.
ASB 14780 markedly ameliorates liver injury and hepatic fibrosis, attenuates the CCl4-induced expression of α-SMA protein and the mRNA expression of collagen 1a2, α-SMA, and TGF-β1 in the liver, and inhibits the expression of monocyte/macrophage markers, CD11b and MCP-1 in vivo, while preventing the recruitment of monocytes/macrophages to the liver.

物理化学性质&存储条件

分子量	582.69
分子式	C31H27NO3 · C4H11NO3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	3-[1-(4-phenoxyphenyl)-3-(2-phenylethyl)-1H-indol-5-yl]propanoic acid 2-amino-2-(hydroxymethyl)propane-1,3-diol salt

参考文献

1. Tomoo T, et al. J Med Chem. 2014 Sep 11;57(17):7244-62.

2. Kanai S, et al. J Pharmacol Exp Ther. 2016 Mar;356(3):604-14.

ASB 14780 (ASB14780;ASB-14780)

生物&药学活性

物理化学性质&存储条件

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ASB 14780 (ASB14780;ASB-14780)

生物&药学活性

物理化学性质&存储条件

参考文献

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