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首页-小分子抑制剂&激动剂-Ras-Raf-MAPK-ERK Pathway-MEK (MAP2K)-AS703026
AS703026

Chemical Structure : AS703026

CAS No.: 1236699-92-5

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AS703026 (Pimasertib;MSC1936369B;AS-703026;AS 703026)

货号: PC-42857Not For Human Use, Lab Use Only.

AS703026 (Pimasertib, MSC1936369B) is a potent, selective, allosteric, orally bioavailable MEK1/2 inhibitor, inhibits the growth of MM cell lines with IC50 of 0.005-2 uM.

规格 价格 库存 数量
25 mg ￥980 In stock
100 mg ￥2480 In stock
200 mg ￥3880 In stock
1 g ￥3880 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

AS703026 (Pimasertib, MSC1936369B) is a potent, selective, allosteric, orally bioavailable MEK1/2 inhibitor, inhibits the growth of MM cell lines with IC50 of 0.005-2 uM.
AS703026 (Pimasertib) has IC50 of 10 nM against INA-6 cells, approximately 10-fold more potent than AZD6244 at inhibiting cytokine-induced osteoclast differentiation in vitro.
AS703026 (Pimasertib) effectively inhibits the growth of D-MUT cells in vitro and in vivo by specific inhibition of the key MEK downstream target kinase ERK.
AS703026 (Pimasertib) also enhances gemcitabine efficacy in pancreatic cancer models by reducing ribonucleotide reductase subunit-1 (RRM1).

物理化学性质&存储条件

分子量 431.2008
分子式 C15H15FIN3O3
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

4-Pyridinecarboxamide, N-[(2S)-2,3-dihydroxypropyl]-3-[(2-fluoro-4-iodophenyl)amino]-

参考文献

1. Kim K, et al. Br J Haematol. 2010 May;149(4):537-49.

2. Yoon J, et al. Cancer Res. 2011 Jan 15;71(2):445-53.

3. Park SJ, et al. Am J Med Sci. 2013 Dec;346(6):494-8.

4. Vena F, et al. Clin Cancer Res. 2015 Dec 15;21(24):5563-77.

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