AS604872 | FP antagonist | Probechem Biochemicals

Chemical Structure : AS604872

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AS604872 (AS 604872)

货号: PC-20528Not For Human Use, Lab Use Only.

AS604872 is a potent and selective prostaglandin F2α receptor (FP) antagonist with a Ki of 35 nM, 158 nM and 323 nM for human, rat and mouse FP receptors, respectively.

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生物&药学活性

AS604872 is a potent and selective prostaglandin F2α receptor (FP) antagonist with a Ki of 35 nM, 158 nM and 323 nM for human, rat and mouse FP receptors, respectively.
AS604872 inhibited spontaneous uterine contractions in pregnant rat near term.
AS604872 delayed parturition induced by either the antiprogesterone RU-486 or the endotoxin lipopolysaccharide.
Combination of AS604872 and ritodrine showed an additive inhibitory effect on spontaneous uterine contractions in rat.

物理化学性质&存储条件

分子量	515.65
分子式	C28H25N3O3S2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	O=C([C@@H]1SCCN1S(=O)(C2=CC=C(C3=CC=CC=C3)C=C2)=O)N[C@H](C4=CC=CC=C4)C5=NC=CC=C5

参考文献

1. Rocco Cirillo, et al. Am J Obstet Gynecol. 2007 Jul;197(1):54.e1-9.

AS604872 (AS 604872)

生物&药学活性

物理化学性质&存储条件

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AS604872 (AS 604872)

生物&药学活性

物理化学性质&存储条件

参考文献

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