AS2677131 | PIKfyve inhibitor | Probechem Biochemicals

Chemical Structure : AS2677131

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AS2677131 (AS 2677131, AS-2677131)

货号: PC-60991Not For Human Use, Lab Use Only.

AS2677131 is a novel potent, oral PIKfyve inhibitor that selectively decreases c-Rel binding to gene promoters of IL-12p40 and IL-1β, regulates cytokine production through PIKfyve-c-Rel pathway ( IL-12p40 IC50=4 nM).

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生物&药学活性

AS2677131 is a novel potent, oral PIKfyve inhibitor that selectively decreases c-Rel binding to gene promoters of IL-12p40 and IL-1β, regulates cytokine production through PIKfyve-c-Rel pathway ( IL-12p40 IC50=4 nM).
AS2677131 inhibits the production of IL-12p40, IL-6 and IL-1β but not TNFα in activated macrophages or dendritic cells, and expression of IgM-induced MHC class II on B cells.
AS2677131 reduces Akt phosphorylation in IFNγ/LPS-stimulated RAW264.7 cells.
AS2677131 greatly increases cell size with many small vesicles in the cytoplasm.

物理化学性质&存储条件

分子量	470.577
分子式	C27H30N6O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	rel-N-{6'-[(2R,6S)-2,6-dimethylmorpholin-4-yl]-3,3'-bipyridin-5-yl}-3-ethyl-2-methyl-1H-pyrrolo[3,2-b]pyridine-5-carboxamide

参考文献

1. Terajima M, et al. Eur J Pharmacol. 2016 Jun 5;780:93-105.

AS2677131 (AS 2677131, AS-2677131)

生物&药学活性

物理化学性质&存储条件

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AS2677131 (AS 2677131, AS-2677131)

生物&药学活性

物理化学性质&存储条件

参考文献

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