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首页-小分子抑制剂&激动剂-NF-κB Pathway-NF-κB-AS2676293
AS2676293

Chemical Structure : AS2676293

CAS No.: 1393999-79-5

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AS2676293 (AS 2676293)

货号: PC-21026Not For Human Use, Lab Use Only.

AS2676293 (AS 2676293) is an orally active small-molecule receptor activator of nuclear factor-κB ligand (RANKL) inhibitor, inhibits RANKL-induced osteoclastogenesis using RAW264 cells with IC50 of 0.19 uM.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

AS2676293 (AS 2676293) is an orally active small-molecule receptor activator of nuclear factor-κB ligand (RANKL) inhibitor, inhibits RANKL-induced osteoclastogenesis using RAW264 cells with IC50 of 0.19 uM.
AS2676293 (0.3-3 mg/kg, oral) inhibited bone loss significantly in RANKL-induced osteopenic mice.
AS2676293 markedly inhibited bone metastasis of human breast cancer cells MDA-MB-231-5a-D-Luc2 as well as tumour-induced osteolysis.
AS2676293 suppressed RANKL-mediated tumour migration in the transwell assay and inhibited bone metastasis of the murine cell line B16F10, which is known not to trigger osteoclast activation.

物理化学性质&存储条件

分子量 378.33
分子式 C18H14F4N4O
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

COC1=CN=C(C2=NC=CC=C2)N=C1NCC3=CC=C(F)C=C3C(F)(F)F

参考文献

1. Junji Miyata, et al. Bioorg Med Chem Lett. 2012 Sep 1;22(17):5681-4.

2. Vagelis Rinotas, et al. Int J Mol Sci. 2023 Jul 10;24(14):11290.

3. Nakai Y, et al. Bone Res. 2019 Jan 3;7:1. doi: 10.1038/s41413-018-0036-5.

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