AS2674723 | 5-HT5A antagonist | Probechem Biochemicals

Chemical Structure : AS2674723

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AS2674723 (AS 2674723, AS-2674723)

货号: PC-49159Not For Human Use, Lab Use Only.

AS2674723 is a potent, selective and brain-penetrating 5-HT5A receptor antagonist with Ki of 0.75, 0.67 and 1.9 nM against human, rat, mouse 5-HT5A receptors, respectively.

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生物&药学活性

AS2674723 is a potent, selective and brain-penetrating 5-HT5A receptor antagonist with Ki of 0.75, 0.67 and 1.9 nM against human, rat, mouse 5-HT5A receptors, respectively.
AS2674723 displays 10-fold greater selectivity for 5-HT5A over 5-HT7 receptor, and no significant affinity for 5-HT2A/2B/2C/3/4/6 receptors.
AS2674723 (0.01-0.03 mg/kg, p.o.) ameliorated scopolamine-induced working memory deficit in mice and improved reference memory impairment in aged rats.

物理化学性质&存储条件

分子量	482.392
分子式	C21H18F4N4O5
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(diaminomethylene)-5-fluoro-8-(2,4,6-trifluorophenyl)-3,4-dihydroisoquinoline-2(1H)-carboxamide fumarate

参考文献

1. Yamazaki M, et al. J Pharmacol Sci. 2015 Mar;127(3):362-9.

AS2674723 (AS 2674723, AS-2674723)

生物&药学活性

物理化学性质&存储条件

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AS2674723 (AS 2674723, AS-2674723)

生物&药学活性

物理化学性质&存储条件

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