AS 2553627 | JAK inhibitor | Probechem Biochemicals

Chemical Structure : AS 2553627

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AS 2553627 (AS2553627, AS-2553627)

货号: PC-60988Not For Human Use, Lab Use Only.

AS 2553627 (AS2553627) is a novel potent, selective pan-JAK inhibitor with IC50 of 0.46, 0.30, 0.14 and 2.0 nM for JAK1, JAK2, JAK3 and TYK2, respectively.

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生物&药学活性

AS 2553627 (AS2553627) is a novel potent, selective pan-JAK inhibitor with IC50 of 0.46, 0.30, 0.14 and 2.0 nM for JAK1, JAK2, JAK3 and TYK2, respectively.
AS 2553627 displays no inhibitory activity against a panel of protein kinases, including SYK and ZAP70 at 1 uM.
AS 2553627 inhibits proliferation of IL-2 stimulated human and rat T cells with IC50 of 2.4 and 4.3 nM, respectively, inhibits the proliferation of TF-1 cells stimulated with EPO with IC50 of 12 nM.
AS 2553627 effectively prevents chronic rejection in rat cardiac allografts in rat cardiac transplant model alone or co-administration with tacrolimus.

物理化学性质&存储条件

分子量	321.384
分子式	C18H19N5O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	3-((3R,4R)-3-(dipyrrolo[2,3-b:2',3'-d]pyridin-1(6H)-yl)-4-methylpiperidin-1-yl)-3-oxopropanenitrile

参考文献

1. Nakamura K, et al. Eur J Pharmacol. 2017 Feb 5;796:69-75.

2. Nakamura K, et al. Transpl Immunol. 2017 Oct 5. pii: S0966-3274(17)30038-2.

AS 2553627 (AS2553627, AS-2553627)

生物&药学活性

物理化学性质&存储条件

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AS 2553627 (AS2553627, AS-2553627)

生物&药学活性

物理化学性质&存储条件

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