AS2541019 |CAS:2098906-98-8 Probechem Biochemicals

Chemical Structure : AS2541019

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AS2541019 (AS 2541019)

货号: PC-63185Not For Human Use, Lab Use Only.

AS2541019 is a novel potent, selective, orally active PI3Kδ inhibitor with IC50 of 20.1 nM, >100-fold selectivity over other PI3K isoforms.

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生物&药学活性

AS2541019 is a novel potent, selective, orally active PI3Kδ inhibitor with IC50 of 20.1 nM, >100-fold selectivity over other PI3K isoforms.
AS2541019 inhibits Akt phosphorylation in human Ramos B cell line with IC50 of 14.3 nM.
AS2541019 effectively inhibits anti-IgM stimulated B cell proliferation and human B cell proliferation with IC50 of 4.3 and 3.6 nM, respectively.
AS2541019 significantly inhibits both T-dependent and T-independent de novo antibody production in peripheral blood in vivo.
AS2541019 significantly prolongs graft survival time by inhibiting xenoreactive antibody production in rat concordant xenotransplant model.

物理化学性质&存储条件

分子量	529.593
分子式	C26H33F2N7O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-[trans-4-({6-[2-(difluoromethyl)-1H-benzimidazol-1-yl]-2-(morpholin-4-yl)pyrimidin-4-yl}oxy)cyclohexyl]-2-(dimethylamino)acetamide

参考文献

1. Marui T, et al. Eur J Pharmacol. 2018 Mar 5. pii: S0014-2999(18)30133-X.

AS2541019 (AS 2541019)

生物&药学活性

物理化学性质&存储条件

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AS2541019 (AS 2541019)

生物&药学活性

物理化学性质&存储条件

参考文献

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