AS2444697 | IRAK4 inhibitor | Probechem Biochemicals

Chemical Structure : AS2444697

CAS No.: 1287665-60-4

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AS2444697 (AS-2444697)

货号: PC-60997Not For Human Use, Lab Use Only.

AS2444697 is a potent, selective, orally bioavailable IRAK4 inhibitor (IC50=21 nM), potently inhibits human and rat IRAK-4 activity with subnanomolar order, >30-fold selectivity over IRAK-1.

规格	价格	库存
5 mg	￥980	In stock
10 mg	￥1480	In stock
25 mg	￥2580	In stock
50 mg	￥4280	In stock
100 mg		Get quote

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生物&药学活性

AS2444697 is a potent, selective, orally bioavailable IRAK4 inhibitor (IC50=21 nM), potently inhibits human and rat IRAK-4 activity with subnanomolar order, >30-fold selectivity over IRAK-1.
AS2444697 inhibited IL-1β- or TLR ligand lipopolysaccharide (LPS)-induced IL-6 production in human lung alveolar epithelial cells, fibroblast-like synoviocytes, and peripheral blood mononuclear cells.
AS2444697 significantly reduces urinary protein excretion and preventd the development of glomerulosclerosis and interstitial fibrosis without affecting the blood pressure in mice model of chronic kidney disease.

物理化学性质&存储条件

分子量	432.865
分子式	C19H21ClN6O4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-[3-carbamoyl-1-(tetrahydro-2H-pyran-4-yl)-1H-pyrazol-4-yl]-2-(2-methylpyridin-4-yl)-1,3-oxazole-4-carboxamide hydrochloride

参考文献

1. Kondo M, et al. Naunyn Schmiedebergs Arch Pharmacol. 2014 Oct;387(10):909-19.

2. Imanishi J, et al. Arthritis Rheum 63:S390.

AS2444697 (AS-2444697)

生物&药学活性

物理化学性质&存储条件

参考文献

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AS2444697 (AS-2444697)

生物&药学活性

物理化学性质&存储条件

参考文献

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