AS2030680 | 5-HT5A antagonist | Probechem Biochemicals

Chemical Structure : AS2030680

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AS2030680 (AS 2030680)

货号: PC-49161Not For Human Use, Lab Use Only.

AS2030680 is a potent, selective and brain-penetrating 5-HT5A receptor antagonist with Ki of 0.58, 1.1 and 2.6 nM against human, rat, mouse 5-HT5A receptors, respectively.

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生物&药学活性

AS2030680 is a potent, selective and brain-penetrating 5-HT5A receptor antagonist with Ki of 0.58, 1.1 and 2.6 nM against human, rat, mouse 5-HT5A receptors, respectively.
AS2030680 displays 15-fold greater selectivity for 5-HT5A over 5-HT1A, 5-HT2B, and 5-HT7 receptors, and no significant affinity for 5-HT2A/3/4 receptors.
AS2030680 (0.01-0.03 mg/kg, p.o.) ameliorated scopolamine-induced working memory deficit in mice and improved reference memory impairment in aged rats.

物理化学性质&存储条件

分子量	428.209
分子式	C17H13BrF3N3O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(diaminomethylene)-4-(2,4,6-trifluorophenyl)-2H-chromene-6-carboxamide hydrobromide

参考文献

1. Yamazaki M, et al. J Pharmacol Sci. 2015 Mar;127(3):362-9.

AS2030680 (AS 2030680)

生物&药学活性

物理化学性质&存储条件

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AS2030680 (AS 2030680)

生物&药学活性

物理化学性质&存储条件

参考文献

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