AS1938909 | SHIP2 inhibitor | Probechem Biochemicals

Chemical Structure : AS1938909

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AS1938909 (AS 1938909)

货号: PC-21454Not For Human Use, Lab Use Only.

AS1938909 is a potent, selective and competitive SHIP2 inhibitor with Ki value of 0.44 uM (human SHIP2), shows significant selectivity over other related phosphatases.

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生物&药学活性

AS1938909 is a potent, selective and competitive SHIP2 inhibitor with Ki value of 0.44 uM (human SHIP2), shows significant selectivity over other related phosphatases.
AS1938909 shows weak activity against human SHIP1 with Ki and IC50 values of 12 and 21 μM respectively.
AS1938909 shows potent inhibitory activity against human and mouse SHIP2 in a concentration-dependent manner, with IC50 values of 0.57 and 0.18 μM, respectively.
AS1938909 (1 nM) increases Akt phosphorylation and glucose consumption in L6 myotubes.
AS1938909 increases glucose uptake and GLUT1 mRNA in L6 and C2C12 myotubes.

物理化学性质&存储条件

分子量	428.27
分子式	C19H13Cl2F2NO2S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	3-[(2,4-dichlorobenzyl)oxy]-N-(2,6-difluorobenzyl)thiophene-2-carboxamide

参考文献

1. Akira Suwa, et al. Eur J Pharmacol. 2010 Sep 10;642(1-3):177-82.

AS1938909 (AS 1938909)

生物&药学活性

物理化学性质&存储条件

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AS1938909 (AS 1938909)

生物&药学活性

物理化学性质&存储条件

参考文献

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