AS1928370 |CAS:1345614-89-2 Probechem Biochemicals

Chemical Structure : AS1928370

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AS1928370 (ASP-8370;ASP8370)

货号: PC-35235Not For Human Use, Lab Use Only.

AS1928370 (ASP8370) is a potent, selective, orally available TRPV1 antagonist with IC50 of 0.51 uM, shows no inhibitory effects on TRPV4, TRPA11, and TRPM8 at 10 uM.

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生物&药学活性

AS1928370 (ASP8370) is a potent, selective, orally available TRPV1 antagonist with IC50 of 0.51 uM, shows no inhibitory effects on TRPV4, TRPA11, and TRPM8 at 10 uM.
AS1928370 (ASP8370) demonstrates high aqueous solubility (pH6.8, >100 uM), satisfactory stability in human liver microsomes, and reduced CYP3A4 inhibition.
AS1928370 (ASP8370) improves capsaicin-induced secondary hyperalgesia and mechanical allodynia in an L5/L6 spinal nerve ligation model in rats with respective ED50s of 0.17 and 0.26 mg/kg p.o.

物理化学性质&存储条件

分子量	453.586
分子式	C29H31N3O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(R)-N-(1-methyl-2-oxo-1,2,3,4-tetrahydro-7-quinolyl)-2-[(2-methylpyrrolidin-1-yl)methyl]biphenyl-4-carboxamide

参考文献

1. Oka H, et al. Bioorg Med Chem. 2018 Jul 23;26(12):3716-3726.

2. Watabiki T, et al. J Pharmacol Exp Ther. 2011 Mar;336(3):743-50.

3. Watabiki T, et al. Biol Pharm Bull. 2011;34(7):1105-8.

AS1928370 (ASP-8370;ASP8370)

生物&药学活性

物理化学性质&存储条件

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AS1928370 (ASP-8370;ASP8370)

生物&药学活性

物理化学性质&存储条件

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