AS1907417 | GPR119 agonist | Probechem Biochemicals

Chemical Structure : AS1907417

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AS1907417 (AS 1907417)

货号: PC-20440Not For Human Use, Lab Use Only.

AS1907417 is a potent, selective GPR119 agonist with cAMP EC50 of 1.1 uM (human GPR119).

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生物&药学活性

AS1907417 is a potent, selective GPR119 agonist with cAMP EC50 of 1.1 uM (human GPR119).
AS1907417 is inactive towards several other GPCRs, including the b-adrenergic and GLP-1 receptors.
AS1907417 (0.1 to 10 uM) resulted in a concentration-dependent increase in GSIS at high glucose levels (22.4 mM) in mouse pancreatic β-cell line MIN6-B1, induces human insulin promoter activity.
A single dose of AS1907417 improved glucose tolerance, but did not affect plasma glucose or insulin levels.
AS1907417 improved plasma glucose, plasma insulin, pancreatic insulin content, lipid profiles, and increased pancreatic insulin and pancreatic and duodenal homeobox 1 (PDX-1) mRNA levels in db/db mice.

物理化学性质&存储条件

分子量	393.50
分子式	C19H27N3O4S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4-[1-(2-cyclobutyl-6,6-dioxo-5,7-dihydrothieno[3,4-d]pyrimidin-4-yl)piperidin-4-yl]butanoic acid

参考文献

1. Shigeru Yoshida, et al. Biochem Biophys Res Commun. 2010 Oct 1;400(4):745-51.

AS1907417 (AS 1907417)

生物&药学活性

物理化学性质&存储条件

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AS1907417 (AS 1907417)

生物&药学活性

物理化学性质&存储条件

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