AS1670542 | TPO receptor agonist | Probechem Biochemicals

Chemical Structure : AS1670542

加入收藏

AS1670542 (AS-1670542)

货号: PC-26118Not For Human Use, Lab Use Only.

规格	价格	库存	数量
50 mg		Get quote
100 mg		Get quote
250 mg		Get quote

获取报价单

* 请选择数量再加入购物车

or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

生物&药学活性

AS1670542 is a potent, selective, orally-active human thrombopoietin receptor (TPO receptor) agonist, concentration dependently promotes proliferation of Ba/F3 cells expressing human TPO receptor with EC50 of 1.9 nM.
AS1670542 promotes megakaryocyte colony formation from human cord blood CD34+ cells in a concentration-dependent fashion (EC50=260 nM).
AS1670542 induced tyrosine phosphorylation of STAT5 in human blood platelets, but not rhTPO induced tyrosine phosphorylation of STAT5 in beagle dogs, rats, and cynomolgus monkeys.
AS1670542 (0.3 and 1 mg/kg/day) significantly increased the number of human platelets on in vivo human platelet production in NOD/SCID mice transplanted with human fetal liver CD34+ cells.

物理化学性质&存储条件

分子量	580.54
分子式	C25H27Cl2N5O3S2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	1-(3-chloro-5-((4-(4-chlorothiophen-2-yl)-5-((cyclobutyl(methyl)amino)methyl)thiazol-2-yl)carbamoyl)pyridin-2-yl)piperidine-4-carboxylic acid

参考文献

1. Abe M, et al. Eur J Pharmacol. 2011 Jan 10;650(1):58-63.

AS1670542 (AS-1670542)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

AS1670542 (AS-1670542)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

Get Quotation Now

* Indicates a Required FieldYour information is safe with us.