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首页-小分子抑制剂&激动剂-Metabolic Enzyme/Protease-NAMPT-AS1604498
AS1604498

Chemical Structure : AS1604498

CAS No.: 361465-74-9

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AS1604498 (AS 1604498;AS-1604498)

货号: PC-61000Not For Human Use, Lab Use Only.

AS1604498 is a potent nicotinamide phosphoribosyl transferase (NAMPT) inhibitor with IC50 of 44 nM.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    AS1604498 is a potent nicotinamide phosphoribosyl transferase (NAMPT) inhibitor with IC50 of 44 nM.
    AS1604498 inhibits THP-1 and K562 cell line growth with the IC50 of 198 nM and 673 nM, respectively.
    AS1604498 reduces intracellular NAD and induces apoptosis.

    物理化学性质&存储条件

    分子量 319.364
    分子式 C19H17N3O2
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20 °C 12 个月; 4°C 6 个月
    配置液
    -80 °C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    N-(3-(1H-imidazol-1-yl)propyl)-5-(phenylethynyl)furan-2-carboxamide

    参考文献

    1. Takeuchi M, et al. Biol Pharm Bull. 2014;37(1):31-6.

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