Chemical Structure : AS105
CAS No.: 1026029-18-4
货号: PC-72972Not For Human Use, Lab Use Only.
AS105 (AS-105) is a highly potent, ATP-competitive CaMKII inhibitor, inhibits CaMKIIδ with IC50 of 8 nM, Ki of 3 nM.
规格 | 价格 | 库存 | 数量 |
---|---|---|---|
2 mg | ¥2280 | In stock | |
5 mg | ¥3880 | In stock | |
10 mg | ¥5880 | In stock | |
25 mg | Get quote | ||
50 mg | Get quote | ||
100 mg | Get quote |
大包装,大折扣!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
AS105 (AS-105) is a highly potent, ATP-competitive CaMKII inhibitor, inhibits CaMKIIδ with IC50 of 8 nM, Ki of 3 nM.
AS105 is also effective against autophosphorylated CaMKII (in contrast to the commonly used allosteric CaMKII-inhibitor KN-93).
In isolated atrial cardiomyocytes from human donors and ventricular myocytes from CaMKIIδC-overexpressing mice with heart failure, AS105 effectively reduced diastolic SR Ca2+ leak by 38% to 65% as measured by Ca2+-sparks or tetracaine-sensitive shift in [Ca2+]i.
AS105 effectively reduced SR Ca2+-leak, thus improving SR Ca2+-accumulation and reducing cellular arrhythmogenic correlates, without negatively influencing excitation-contraction coupling.
分子量 | 339.827 | |
分子式 | C18H18ClN5 | |
外观性状 | Solid | |
储存条件 |
|
|
Solubility |
10 mM in DMSO (3.4 mg/mL) |
|
Chemical Name/SMILES |
N1-(3-(2-((3-chlorophenyl)amino)pyrimidin-4-yl)phenyl)ethane-1,2-diamine |
1. Stefan Neef, et al. J Mol Cell Cardiol. 2018 Feb;115:73-81.
备案号:沪ICP备16042516号-1 Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright