AS-605240 |CAS:648450-29-7 Probechem Biochemicals

Chemical Structure : AS-605240

CAS No.: 648450-29-7

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AS-605240 (AS605240;AS 605240)

货号: PC-42311Not For Human Use, Lab Use Only.

AS-605240 (AS605240) is a potent, selective, ATP-competitive, orally active PI3Kγ inhibitor with IC50 of 8 nM.

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25 mg	￥1280	In stock
50 mg	￥1980	In stock
100 mg	￥3580	In stock
500 mg		Get quote
1 g		Get quote

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生物&药学活性

AS-605240 (AS605240) is a potent, selective, ATP-competitive, orally active PI3Kγ inhibitor with IC50 of 8 nM.
AS-605240 displays 30-fold selectivity for PI3Kδ、β, 7.5-fold selectivity over PI3Kα.
AS-605240 inhibits C5a-mediated PKB phosphorylation in RAW264 mouse macrophages (IC50=90 nM).
AS-605240 reduces neutrophil chemotaxis in vivo and suppresses joint inflammation and damage in mouse models of RA.

物理化学性质&存储条件

分子量	257.2679
分子式	C12H7N3O2S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	DMSO: 5.8 mg/mL (Need warming)
Chemical Name/SMILES	2,4-Thiazolidinedione, 5-(6-quinoxalinylmethylene)-

参考文献

1. Camps M, et al. Nat Med. 2005 Sep;11(9):936-43.

2. Fougerat A, et al. Circulation. 2008 Mar 11;117(10):1310-7.

3. Dutra RC, et al. Br J Pharmacol. 2011 May;163(2):358-74.

4. Kobayashi N, et al. Proc Natl Acad Sci U S A. 2011 Apr 5;108(14):5753-8.

AS-605240 (AS605240;AS 605240)

生物&药学活性

物理化学性质&存储条件

参考文献

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AS-605240 (AS605240;AS 605240)

生物&药学活性

物理化学性质&存储条件

参考文献

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