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首页-小分子抑制剂&激动剂-PI3K/Akt/mTOR Pathway-PI3K-AS-252424
AS-252424

Chemical Structure : AS-252424

CAS No.: 900515-16-4

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AS-252424 (AS252424)

货号: PC-22458Not For Human Use, Lab Use Only.

AS-252424 is a potent, and selective inhibitor of phosphoinositide 3-kinase gamma (PI3Kγ) with IC50 of 30 nM, 30-fold selective over PI3Kα, also is a potent ferroptosis inhibitor targeting ACSL4.

规格 价格 库存 数量
5 mg ￥780 In stock
10 mg ￥1180 In stock
25 mg ￥2180 In stock
50 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

AS-252424 is a potent, and selective inhibitor of phosphoinositide 3-kinase gamma (PI3Kγ) with IC50 of 30 nM, 30-fold selective over PI3Kα, also is a potent ferroptosis inhibitor targeting ACSL4.
AS-252424 displays no significant activity over PI3Kβ/δ (IC50>20 uM), as well as excellent selectivity profile against a large set of unrelated protein kinases.
AS-252424 inhibits C5a-mediated PKB/Akt phosphorylation in a concentration-dependent manner in Raw-264 macrophages (IC50=0.228 uM), with no effect on SCF-induced phosphorylation of PKB/Akt in bone marrow derived mast cells.
AS-252424 inhibits preferentially chemokine-induced (PI3Kγ-mediated) but not cytokine-induced (class IA PI3K-mediated) PKB/Akt phosphorylation in the human monocytic cell line THP-1.
AS-252424 decreases leukocyte infiltration in a murine peritonitis model.
AS-252424 also is a potent ferroptosis inhibitor, directly binds to the glutamine 464 of ACSL4 to inhibit its enzymatic activity.

物理化学性质&存储条件

分子量 305.28
分子式 C14H8FNO4S
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(Z)-5-((5-(4-Fluoro-2-hydroxyphenyl)furan-2-yl)methylene)thiazolidine-2,4-dione

参考文献

1. Pomel V, et al. J Med Chem. 2006 Jun 29;49(13):3857-71.

2. Huang Q, et al. Sci Adv. 2024 Mar 29;10(13):eadk1200.

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