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首页-小分子抑制剂&激动剂-Tyrosine Kinase-BTK-AS-1763
AS-1763

Chemical Structure : AS-1763

CAS No.: 2227211-00-7

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AS-1763 (Milrebrutinib, AS1763)

货号: PC-72757Not For Human Use, Lab Use Only.

Milrebrutinib (AS1763, AS-1763) is a potent, selective, noncovalent, and orally available inhibitor of BTK with IC50 of 0.85 nM and 0.99 nM for wild-type BTK and C481S mutant, respectively.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

Milrebrutinib (AS1763, AS-1763) is a potent, selective, noncovalent, and orally available inhibitor of BTK with IC50 of 0.85 nM and 0.99 nM for wild-type BTK and C481S mutant, respectively.
AS-1763 is a next-generation noncovalent BTK inhibitor with significant efficacies in vivo tumor xenograft models.

物理化学性质&存储条件

分子量 578.648
分子式 C33H31FN6O3
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

2-(3-(2-amino-6-(1-(oxetan-3-yl)-1,2,3,6-tetrahydropyridin-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-2-(hydroxymethyl)phenyl)-6-cyclopropyl-8-fluoroisoquinolin-1(2H)-one

参考文献

1. Wataru Kawahata, et al. J. Med. Chem. 2021, 64, 19, 14129–14141.

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