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首页-小分子抑制剂&激动剂-Cell Cycle/DNA Damage-Cyclin-dependent Kinase (CDK)-AS-0141
AS-0141

Chemical Structure : AS-0141

CAS No.: 1402057-88-8

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AS-0141 (Monzosertib, AS0141)

货号: PC-72755Not For Human Use, Lab Use Only.

Monzosertib (AS 0141) is a potent, selective, orally bioavailable CDC7 inhibitor with IC50 of 2.4 nM.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

Monzosertib (AS 0141) is a potent, selective, orally bioavailable CDC7 inhibitor with IC50 of 2.4 nM.
AS-0141 demonstrated excellent kinase selectivity and favorable oral bioavailability in multiple species, and robust in vivo antitumor efficacy in a colorectal cancer xenograft model.

物理化学性质&存储条件

分子量 465.433
分子式 C21H22F3N5O4
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

ethyl (E)-5-((1H-pyrrolo[2,3-b]pyridin-3-yl)methylene)-4-oxo-2-((4-(2,2,2-trifluoroethyl)piperazin-1-yl)amino)-4,5-dihydrofuran-3-carboxylate

参考文献

1. Takayuki Irie, et al. J. Med. Chem. 2021, 64, 19, 14153–14164.

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