AR inhibitor 1ae | AR inhibitor | Probechem Biochemicals

Chemical Structure : AR inhibitor 1ae

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AR inhibitor 1ae (Compound 1ae)

货号: PC-21502Not For Human Use, Lab Use Only.

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生物&药学活性

AR inhibitor 1ae is a small-molecule inhibitor of the androgen receptor activation domain (AR AD) with IC50 of 1.54 uM in androgen-induced PSA-luciferase assays, inhibits AR-V7 transcriptional activity with IC50 of 4.1 uM.
1ae inhibits AR-dependent targets in prostate cancer cells and is more potent in its transcriptional inhibitory effect than EPI-001 (Cat#PC-61678).
1ae significantly reduced tumor volumes in both the LNCaP and LNCaP95-D3 xenograft models.
1ae outperformed enzalutamide in the AR-V7-driven LNCaP95-D3 xenograft model of CRPC.

物理化学性质&存储条件

分子量	452.93
分子式	C26H25ClO5
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(R)-3-(4-((6-((S)-3-chloro-2-hydroxypropoxy)-[1,1'-biphenyl]-3-yl)ethynyl)phenoxy)propane-1,2-diol

参考文献

1. Basu S, et al. Nat Struct Mol Biol. 2023 Dec 4. doi: 10.1038/s41594-023-01159-5.

AR inhibitor 1ae (Compound 1ae)

生物&药学活性

物理化学性质&存储条件

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AR inhibitor 1ae (Compound 1ae)

生物&药学活性

物理化学性质&存储条件

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