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首页-小分子抑制剂&激动剂-Nuclear Receptor/Transcription Factor-Androgen Receptor (AR)-ARVib-7
ARVib-7

Chemical Structure : ARVib-7

CAS No.: 934192-70-8

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ARVib-7 (ARVib7)

货号: PC-26704Not For Human Use, Lab Use Only.

ARVib-7 is a small molecule inhibitor of NDUFS4, a nuclear-encoded subunit of electron transport chain complex I, disrupts OxPhos and induces ferroptosis.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    ARVib-7 is a small molecule inhibitor of NDUFS4 that decreases NDUFS4 protein levels, a nuclear-encoded subunit of electron transport chain complex I, disrupts OxPhos and induces ferroptosis, ARVib-7 is a potent inhibitor of androgen receptor AR/AR variants, inhibits AR-V7 expression.
    ARVib-7 (1 uM) inhibits AR by 91.64% and AR-V7 by 92.06% in CWR22Rv1 prostate cancer cells that express both AR and AR variants.
    ARVib-7 (1 uM) inhibits AR by 93.59% and AR-V7 by 89.20% in CWR22Rv1 cells.
    ARVib-7 (1.5 uM) disrupts the AR/AR-V7 gene expression program in enzalutamide-resistant prostate cancer cells C4-2B MDVR.
    ARVib-7 (1 uM) inhibits AR/AR-V7 protein expression via HSP70/STUB1-mediated ubiquitin-proteasome system regulation in C4-2B MDVR cells.
    ARVib-7 suppresses resistant prostate cancer cell growth and induces apoptosis.
    ARVib-7 (25 mg/kg i.p) suppresseed advanced prostate tumor growth in mice bearing CWR22Rv1 xenografts
    ARVib-7 (150 mg per kg p.o) suppresses advanced prostate tumor growth in mice bearing LuCaP 35CR xenografts.
    ARVib-7 inhibits NDUFS4, disrupts mitochondrial function, and enhances olaparib sensitivity in resistant prostate cancer cells.

    物理化学性质&存储条件

    分子量 350.12
    分子式 C14H8Cl2F3NO2
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20°C 12 个月; 4°C 6 个月
    配置液
    -80°C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    5-chloro-N-(2-chloro-4-(trifluoromethyl)phenyl)-2-hydroxybenzamide

    参考文献

    1. Schaaf ZA, et al. Mol Cancer Ther. 2026 Apr 9. doi: 10.1158/1535-7163.MCT-25-1157. 2. Chengfei Liu, et al. Oncogene. 2021 Sep;40(35):5379-5392.

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