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首页-小分子抑制剂&激动剂-Others-Other Targets-ARUK2007145
ARUK2007145

Chemical Structure : ARUK2007145

CAS No.:

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ARUK2007145 (ARUK 2007145)

货号: PC-21274Not For Human Use, Lab Use Only.

ARUK2007145 is a potent, selective and cell-active PI5P4Kα/γ dual inhibitor with pIC50 of 7.3/8.1, resepctively, shows no activity against PI5P4Kβ.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

ARUK2007145 is a potent, selective and cell-active PI5P4Kα/γ dual inhibitor with pIC50 of 7.3/8.1, resepctively, shows no activity against PI5P4Kβ.
ARUK2007145 shows good activity in the InCELL Pulse target engagement assay (PI5P4Kγ pIC50=7.3).
ARUK2007145 shows a good dual activity in the ADP-Glo assays showing similar activities for PI5P4Kγ+ and PI5P4Kα (fold-selectivity=5).

物理化学性质&存储条件

分子量 384.90
分子式 C18H13ClN4S2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

6-(2-chloropyridin-3-yl)-N-(4-(methylthio)phenyl)thieno[3,2-d]pyrimidin-4-amine

参考文献

1. Gregory G Aldred, et al. RSC Med Chem. 2023 Aug 23;14(10):2035-2047.

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