ARTS mimetic B3

Chemical Structure : ARTS mimetic B3

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货号: PC-22252Not For Human Use, Lab Use Only.

ARTS mimetic B3 is a small-molecule ARTS-mimeticdirectly binds to the ARTS binding pocket in XIAP-BIR3 with KD of 36 uM, stimulates apoptosis in a wide range of cancer cells but not normal PBMC.

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生物&药学活性

ARTS mimetic B3 is a small-molecule ARTS-mimeticdirectly binds to the ARTS binding pocket in XIAP-BIR3 with KD of 36 uM, stimulates apoptosis in a wide range of cancer cells but not normal PBMC.
ARTS mimetic B3 can reduce XIAP levels to promote apoptosis, elevates p53 levels.
ARTS mimetic B3 can disrupt the binding between XIAP and p53, promotes the degradation of XIAP and increases the stability of p53 to promote apoptosis.
ARTS mimetic B3 is able to recapitulate key biochemical and functional properties of ARTS.
The XIAP-antagonist ARTS regulates the levels of p53 by promoting the degradation of XIAP. XIAP directly binds and ubiquitylates p53.

物理化学性质&存储条件

分子量	406.44
分子式	C22H22N4O4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(S)-N1-(1-hydroxy-3-phenylpropan-2-yl)-N2-(4-(1-methyl-1H-imidazole-2-carbonyl)phenyl)oxalamide

参考文献

1. Abbas R, et al. Apoptosis. 2024 Apr 29. doi: 10.1007/s10495-024-01957-2.

ARTS mimetic B3

生物&药学活性

物理化学性质&存储条件

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ARTS mimetic B3

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物理化学性质&存储条件

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