ARTS mimetic A4

Chemical Structure : ARTS mimetic A4

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货号: PC-47055Not For Human Use, Lab Use Only.

ARTS mimetic A4 is a small molecule that mimics the function of the pro-apoptotic ARTS (Sept4_i2) protein, binds the ARTS pocket in XIAP-BIR3, but not cIAP1, specifically promotes degradation of XIAP and induces caspase-mediated cell death.

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生物&药学活性

ARTS mimetic A4 is a small molecule that mimics the function of the pro-apoptotic ARTS (Sept4_i2) protein, binds the ARTS pocket in XIAP-BIR3, but not cIAP1, specifically promotes degradation of XIAP and induces caspase-mediated cell death.
A4 binds to a distinct ARTS binding pocket in the XIAP-BIR3 (baculoviral IAP repeat 3) domain with Kd of 348 nM.
A4 stimulated poly-ubiquitylation and UPS-mediated degradation of XIAP and Bcl-2, but not cIAP1.
ARTS-mimetic A4 is a potent inducer of caspase-9- and caspase-3-mediated apoptotic cell death.

物理化学性质&存储条件

分子量	440.928
分子式	C23H25ClN4O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	methyl 3-(2-(4-benzylpiperazin-1-yl)acetamido)-5-chloro-1H-indole-2-carboxylate

参考文献

1. Dana Mamriev, et al. Cell Death Dis. 2020 Jun 25;11(6):483.

ARTS mimetic A4

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ARTS mimetic A4

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