AR NTD inhibitor 16

Chemical Structure : AR NTD inhibitor 16

CAS No.: 3016437-05-8

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货号: PC-21578Not For Human Use, Lab Use Only.

AR NTD inhibitor 16 is a small molecule inhibitor of androgen receptor N-terminal domain (AR NTD) with IC50 of 0.12 uM in VCaP cell-based GRE2-luciferase reporter gene assays.

规格	价格	库存
5 mg	￥3580	In stock
10 mg	￥5580	In stock
25 mg		Get quote
100 mg		Get quote

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生物&药学活性

AR NTD inhibitor 16 is a small molecule inhibitor of androgen receptor N-terminal domain (AR NTD) with IC50 of 0.12 uM in VCaP cell-based GRE2-luciferase reporter gene assays.
AR NTD inhibitor 16 is more potent than known AR-NTD AF1 binder EPI-001 (IC50=37.4 μM).
AR NTD inhibitor 16 is a tool compound to investigate the pharmacology and engagement of the AR NTD.

物理化学性质&存储条件

分子量	297.38
分子式	C16H15N3OS
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	Benzamide, 3-(1-methyl-1H-indazol-5-yl)-4-(methylthio)-

参考文献

1. Martyn C Henry, et al. ACS Med Chem Lett. 2023 Nov 17;14(12):1800-1806.